In a strategic move, Japan’s RIKEN research institute is aligning with American labs and industry leaders to bolster AI and high-performance computing. This collaboration taps into the expertise of Argonne National Laboratory and partners like Fujitsu and Nvidia. The central aim is to forge next-gen compute infrastructure that advances the US’s overarching Genesis Mission for AI-driven innovation. Key activities include co-developing system software and defining future computing architectures. Furthermore, the alliance focuses on incorporating AI into traditional HPC tasks like modeling and simulation. Expected outcomes are a common software ecosystem and further integration of AI and quantum computing in scientific research. This initiative aligns with broad energy and security goals defined by the US’s Department of Energy.